Monthly Archives: January 2009

Life Science VC Shares 3 Things to Think About

Russo Partners has worked closely with Avalon Ventures’ Court Turner over the years.  Based in San Diego, Avalon Ventures focuses on seed and early stage financing for life science companies located primarily in California and the Northeast. 

The firm, under the leadership of Kevin Kinsella, has helped to finance and build some of the most promiment biopharmaceutical companies, including Vertex Pharmaceuticals, in the space since the early 1980s.

From Court’s position, which is one in which he provides financing and operational support to portfolio companies, he sees the following as three important messages to share with scientists and executives with the earliest stage companies who are looking for funding today:

1. Raise an Amount for Success — Not just to get Financed!

Size your financing request so that you have six to nine months of runway after the next planned value inflection point. A company forecast of expenses and execution must leave some room for setback or redirection based on new data. Presentations that show the last penny being spent on the day of value inflection are viewed immediately as unrealistic and raise questions about the rest of the timelines and planning parameters for the company.

2. Execution Plays Need Operational Leaders

If you are pitching a story that involves the execution of a tight and complicated clinical path, your company’s management team must include a leader with proven experience in handling this. Your CEO cannot — and should not — be the original scientific founder if this individual doesn’t have late-stage clinical trial experience under his or her belt and the next value inflection point relies on clinical and regulatory hurdles.

3. Expect Your Financing to be Tranched

In today’s market, investors are less likely to commit the full financing on day No. 1. The days of VCs playing parents and handing out allowances as quarterly and annual “chores” are completed successfully are upon us. With this in mind, you should be ready to break down your two-year plan into six- and nine-month views with incremental milestones.

Here is Court’s bio. You can reach him at court@avalon-ventures.com.

Court R. Turner, J.D., joined Avalon Ventures in January 2008, focusing on the formation and strategic operations of the Avalon VIII portfolio companies. Currently, Mr. Turner is the Chief Operating Officer of Carolus Therapeutics, Afraxis, Inc., Otonomy, Inc., and Zacharon Pharmaceuticals. Prior to joining the Avalon team, Mr. Turner spent over 10 years of his career within companies in the San Diego biotechnology community. Starting in 1997, Mr. Turner joined Aurora Biosciences Corporation (acquired by Vertex Pharmaceuticals in 2001) in their Legal and Strategic Alliances departments focused on technology licensing, business development and a myriad of corporate legal matters facing a public company, including SEC filings and M&A transactions. In June 2002, Mr. Turner joined Kalypsys, Inc., a then start-up small molecule drug discovery company. During his tenure at Kalypsys, the company grew from 15 to more than 125 employees with an impressive product pipeline and three rounds of financing totaling more than $170M. Mr. Turner was a member of the Kalypsys Executive Management Team. He received a Bachelor’s Degree from San Diego State University and a Juris Doctor degree from the University of San Diego School of Law.

Video Carries Stem Cell Story Worldwide

12:01 a.m. EST on Jan. 23:Geron’s news release about the FDA’s green light for the world’s first clinical trial of a human embryonic stem cell therapy crosses BusinessWire. At the same time, a micro-site dedicated to the news appears on Geron’s Web site complete with animation and video produced by the Russo Partners/Geron team. Click here to watch the animation and video.

12:02 a.m. EST:AP, Bloomberg, CNBC.com, Financial Times, Times of London, The New York Times and The Wall Street Journal post the first in-depth stories online — and the story hits the streets in print in the U.K.  These first-mover stories are the results of the Russo Partners/Geron team’s embargoed outreach the day before.

7:31 a.m. EST: Diane Sawyer kicks off the national broadcast coverage of the story on ABC’s Good Morning America with an exclusive segment taped months earlier at Geron’s offices in Menlo Park, Calif.  As part of the segment, ABC shows viewers the animation and video of stem cell therapy production.  Diane Sawyer rounds out the segment with live interviews of the chairman of the Christopher & Dana Reeve Foundation and a stem cell research program head at the University of Michigan.  Both in-studio guests speak of the remarkable accomplishment of Geron.

9 a.m. EST:Geron’s president and CEO, Dr. Tom Okarma, kicks off a conference call and Webcast for members of the investment community and media.  Participants view the animation and video segment while listening to voice-overs taped by Dr. Okarma.

9:30 a.m. EST:Geron distributes the animation and video segment via satellite to TV networks and stations as part of a B-roll package.

9:31 a.m. EST: The Russo Partners/Geron team completes its assistance of Webmasters in loading the animation and video segment to publications’ Web sites for connection to articles — or for use as standalone stories.  One example is Beckey Bright and Ron Winslow’s segment on The Wall Street Journal’s Web site. Click here to watch the segment.

10 a.m. EST: Tom Okarma begins his first of many live and taped TV news interviews arranged by the Russo Partners/Geron team.  From a studio on the campus of Stanford University, Dr. Okarma explains the significance of today’s news to on-air talent — and, ultimately, their viewers — with CNBC, MSNBC, NBC Nightly News, CNN and CBS Evening News.  Geron’s animation and video segment are featured prominently in each interview.

Midday:The first of the broadcast monitoring reports rolls into the Russo Partners/Geron “media base camp” at Russo Partners’ New York City office.  The numbers: Close to 1,000 airings on 500 networks/stations in more than 150 markets — with a reach of more than 100 million viewers.    

Since then, the numbers have exploded, thanks to the well-produced video that the Russo Partners/Geron team had in its toolkit. 

WSJ Health Blog's Scott Hensley

WSJ Health Blog's Scott Hensley

As print and broadcast journalists with whom we work have communicated to us regularly, if we have significant news, the journalists want video.  Scott Hensley, the editor of The Wall Street Journal’s Health Blog and a longtime healthcare reporter, participated in a roundtable discussion with Russo Partners’ staff members and pointed out the references to wsj.com stories in front-page print articles.  Scott’s message was that video was ideal for lifting news from the pages of the newspaper and carrying it far and wide as complementary to what one would see on television.  This message was clearly evident in the case of Geron and has led other Russo Partners’ clients to think through and develop — with Russo Partners’ guidance — the video components of their own PR toolkits.

Newswires Still Important in Web 2.0 Media World

When is the last time you successfully pitched a story to a reporter with a newswire? If you haven’t worked with the newswires lately and you have a story with national or international significance, the newswires should be your first stop as the so-called first movers of news. 

Russo Partners demonstrated this successfully last week with the embargoed pitch of a cardiology-focused story to AP, Reuters and Bloomberg reporters in the U.S. and to those with news services in Germany and the U.K. Equipped with data published in the New England Journal of Medicine, Russo Partners presented the reporters with an easy-to-understand business/consumer angle of how the measurement of coronary artery bloodflow with a device developed by a Swedish company, Radi Medical Systems, enabled physicians to determine whether or not a stent  — a tiny mesh device used to hold open clogged arteries — was necessary.  

As the campaign moved forward, physician spokespersons prepared by Russo Partners delivered the FAME study details and the meaning of the data through telephone interviews with the newswire reporters. Communications tools used as part of the pitch included a news release, study backgrounder and video package.  The end result:  hundreds of articles in print and online publications as the result of the newswires’ distribution.  Moreover, producers with broadcast news outlets used the newswires as sources of health segments that aired as part of nightly newscasts.

For Radi Medical Systems and St. Jude Medical, which acquired Radi in December, the strategy, tactics and results were a homerun.  Success on this front with the newswires was matched by Russo Partners with success in the cardiology trade publications — print and online.

Next up is the development of additional PR strategies and tactics to parlay last week’s success into ongoing successes in support of  product sales efforts. Once again, the preliminary focus on newswires proved to be beneficial to Russo Partners’ work in distributing important healthcare news far and wide.

Here’s the AP story as it ran in a Wisconsin newspaper:

cathlab2-mini

Stents may be overused

Blood flow test may be solution – study

Several reports in recent years have suggested that stents and artery-opening angioplasty procedures were being overused in non-emergency cases, often without giving medicine alone a chance to work. Concern about stent complications also has made doctors more cautious about elective angioplasty.

“It’s really raised a lot of questions about when is it appropriate,” said Dr. Robert Harrington, director of the Duke Clinical Research Institute, who had no role in the new study.

The finding that blood-flow testing may help guide these decisions “adds another parameter for us to consider,” he said.

The test has been around for some years but is used in only about 10 percent of angioplasties now, several heart specialists said.

More than 1 million angioplasties are done in the United States each year, and about half are the type in this study – non-emergency cases involving people with narrowings in two or more major heart arteries.

The study was done in the United States and Europe, and involved 1,005 people who were having chest pain because of reduced blood flow to the heart or were recovering from a mild heart attack. All were scheduled to have angioplasty based on the usual test – an X-ray called an angiogram, in which a dye is injected so doctors can see artery narrowings.

Half of the study participants had their narrowed areas treated with angioplasty and stents, as indicated by angiograms alone.

The rest were given a blood-flow test. Doctors place a wire in the artery and measure pressure in front of and beyond the narrowing. This tells whether the narrowing is keeping a big amount of blood from getting through to the heart. In this group, only narrowings that significantly impeded blood flow were treated with angioplasties and stents.

Results: people given the blood-flow test received on average, roughly two stents versus roughly three for the others.

A year later, only 13 percent of them had died, suffered a heart attack or needed further artery treatment, versus 18 percent of those treated on the basis of angiograms alone. Rates of chest pain at one year were similar.

With the blood-flow test, “we were able to more accurately or more judiciously place stents,” and decide which arteries to skip, said Dr. William Fearon, a Stanford University cardiologist who helped lead the study.

Between 5 and 10 percent of those given the blood-flow test were able to skip angioplasty and stents altogether, and were prescribed medicines instead, he said.

The study was mostly paid for by Radi Medical Systems Inc., a Swedish company that makes the wire used in the blood-flow test and was recently acquired by St. Jude Medical of St. Paul, Minnesota. Several study leaders have consulted or been paid speakers for Radi or various stent makers.

The Radi wire, with a sensor that does the pressure measurement, costs about $750 versus $100 for an ordinary angioplasty wire. But it likely saves money by avoiding pricier stents, which cost $2,000 and up, and possibly some cardiac stress tests, which cost $1,000 or more, Fearon and other heart specialists said.

A second study should quickly be done to see if the benefit can be confirmed, justifying routine use of the blood-flow test, said Dr. Stephen Ellis, a Cleveland Clinic cardiologist who wrote an editorial accompanying the study.

“If validated, the results really should improve medical care,” he said.
 

MILWAUKEE (AP) – A new study gives fresh evidence that many people with clogged heart arteries are being overtreated with stents, and that a simple blood-flow test might help prevent unnecessary care.

Fewer deaths, heart attacks and repeat procedures occurred when doctors implanted fewer of these tiny artery props, using the blood-flow test to decide when they were truly needed, the study found.

Results were published in Thursday’s New England Journal of Medicine.

Russo Partners, Blue State Digital Form Alliance to Help Healthcare Companies Build, Mobilize Online Communities

bsd-imageRusso Partners and Washington-based Blue State Digital have formed an alliance to help healthcare companies at all stages to build and mobilize online communities. Through a combined service offering, the agencies will work together to integrate companies’ offline, online and viral communications.  Blue State Digital has received numerous accolades for its work for Barack Obama, other politicians and companies worldwide. To learn more about the agency, check out www.bluestatedigital.com.

Gotta Have vs. Nice to Have: Words from a Leading MedTech VC

 

Versant Ventures' Ross Jaffe

Versant Ventures' Ross Jaffe

In a week of more than 100 meetings with clients, VCs, portfolio managers and journalists at the JPMorgan Healthcare Conference, we had a chance to catch up with Versant Ventures’ Ross Jaffe. One of the founders of Versant in 1999, Ross specializes in early stage investing in medical device companies.

As we chatted about companies with which we both work, we turned the discussion to what executives who are looking for VC funding for their medtech businesses should think about at the start of a challenging year. As Ross pointed out, executives are facing a double whammy: How do they deal with the current financial markets? And what can they expect in terms of the incoming administration’s healthcare reform? Both questions are top-of-mind among company executives and VCs alike.

To Ross and his Versant partners, companies must justify — now more than ever — why their products are mission critical to healthcare.  This means there must be compelling reasons for the companies’ technologies.  Long gone are the days of build it and they — the users of the technologies — will come. 

Ross said he’s staying away from companies whose products would be viewed as nice to have by doctors and aiming for companies whose products will be critical to making the practice of medicine more cost-effective.  These are the “gotta haves” for him.

Along with compelling reasons for the technologies, Ross wants to see bodies of clinical data that demonstrate the technologies work. Don’t have this today?  Go and get it or face a challenging road to securing funding. 

And what about the companies that Ross has already funded? Be capital efficient. Remain visible. Demonstrate that you are honing your focus.  Visibility and focus lend themselves to our work at Russo Partners as healthcare communicators.  As Ross noted, good PR is critical for medtech companies as long as it, too, is focused on supporting current business initiatives. 

We expect to see a lot more of Ross and Versant Ventures as Russo Partners moves ahead with extensive medtech PR programs.

More on Versant Ventures’ Ross Jaffe:

Ross brings significant clinical insight and venture capital experience to Versant’s investing efforts. Ross co-founded Versant Ventures in 1999 after spending nine years at Brentwood Venture Capital where, as a general partner, he led investments in medical devices, drug delivery, and healthcare information systems companies.

Ross is a board-certified internist, having completed his residency training in Internal Medicine/Primary Care at the University of California, San Francisco, where he remained a part-time attending physician until 1995. Before and during medical school, he was an Analyst for Lewin and Associates, a healthcare consulting firm, and a Research Associate at Dartmouth Medical School.

Ross has served as a director of St. Francis Medical Technologies (sold), Therasense (sold), Novacept (sold), Micro Interventional Systems (sold), Aradigm (public), Webster Laboratories (sold), Atrionix (sold), and Pro•Duct Health (sold). He currently serves on the boards of Ablation Frontiers, Acclarent, Calypso Medical Technologies, ICS, Insulet (NASDAQ: PODD), Portaero and Vital Therapies. He is also a director of the Western Association of Venture Capitalists (WAVC) and a member of the National Venture Capital Association (NVCA) Medical Industry Group. Ross earned his BA in Policy Studies from Dartmouth in 1980, his MD from Johns Hopkins in 1985, and his MBA from Stanford in 1990.